ABSTRACT
Objective The objectives of present study is to investigate the safety and efficacy of pelvic exenteration (PE) for the treatment of pelvic malignancies in urology department.Methods From April 2010 to December 2014,20 patients with primary or recurrent pelvic malignancy accepted anterior pelvic exenteration (APE) or total pelvic exenteration (TPE) surgery,including 7 males and 13 females,ranged from 35 to 87 years old with an average of 65 years old.Ten case accepted APE and 10 for TPE.The ilium conduit was done in 5 cases for APE and 6 cases for TPE as urinary diversion,cutaneous ureterostomy was done in 5 cases for APE and 4 cases for TPE as urinary diversion.There were 6 cases primary tumor in APE group and 3 primary tumors in TPE.All of the patients had 13 cases of the urinary tract tumor group,and none of the urinary tract tumor group in 7 cases.There were 4 cases received preoperative chemotherapy in the urinary tract tumor group.No case received preoperative radiotherapy.3 cases received preoperative chemotherapy in none of the urinary tract tumor group,3 cased received preoperative radiotherapy.After induction of general anesthesia using a laryngeal mask for airway management.All patients took the abdominal incision,then dissected lymph nodes on both sides of the iliac vessels,freed bilateral ureters to the end of the swollen bladder,separated the peritoneal space.The bilateral vas deferens was cutted and ligated,then isolated and ligated the seminal vesicles between the posterior wall of the bladder and the anterior wall of the rectum.Lateral ligaments of bladder was cuted,then cuted ligament of prostate and puboprostatic ligament,sutured and cut deep vein of penis.Urethra of apex prostate was freed and cuted.Female patients needed to free the uterus and the posterior wall,cut the cardinal ligament and round ligament of uterus,isolate the posterior wall of the uterus to the posterior vaginal wall.Rectal resection adopted Miles operation.And sigmoid colostomy was performed on the left side of the abdominal wall.The perioperative characters,pathological results and patients' survival data were collected and analyzed.Results The average operation time for APE was 3.8 hours and 5.2 hours for TPE (P =0.173).Median length of hospital stay was 17.9 (7-47) days.The median blood loss was 300ml (80-2 500 ml) for APE and 400ml (50-6 000 ml) for TPE (P =0.909).The median follow-up time was 12.5 months (1-41months).The estimated 2-year survival rate for APE was 55.6％ and 45.0％ for TPE (P =0.642).Urinary system tumors group and non urinary system tumors group were analyzed and compared,The median survival time was 28 months and 13 months (P =0.538) in the two groups.The incidence of gastrointestinal complications of urinary system tumors and non-urinary system tumors was 7.7％ and 28.6％,incision complications was 7.7％ and 28.6％.Complications of urinary diversion only occurred in the non urologic tumor group,the incidence was 14.3％.The incidence of transfusion in two groups was 46.2％ and 28.6％.Conclusions Pelvic exenteration (APE and TPE) could be a safe and reliable choice for local advanced primary and recurrent pelvic malignancy.Even for the recurrent malignancies,the survival results of the patients were satisfactory.